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Article

Rev1 overexpression accelerates N-methyl-N-nitrosourea (MNU)-induced thymic lymphoma by increasing mutagenesis.

Cancer science - 1 Jun 2024

Sasatani Megumi, Xi Yang, Daino Kazuhiro, Ishikawa Atsuko, Masuda Yuji, Kajimura Junko, Piao Jinlian, Zaharieva Elena Karamfilova, Honda Hiroaki, Zhou Guanyu, Hamasaki Kanya, Kusunoki Yoichiro, Shimura Tsutomu, Kakinuma Shizuko, Shimada Yoshiya, Doi Kazutaka, Ishikawa-Fujiwara Tomoko, Sotomaru Yusuke, Kamiya Kenji

Abstract excerpt

Rev1 has two important functions in the translesion synthesis pathway, including dCMP transferase activity, and acts as a scaffolding protein for other polymerases involved in translesion synthesis. However, the role of Rev1 in mutagenesis and tumorigenesis in vivo remains unclear. We previously generated Rev1-overexpressing (Rev1-Tg) mice and reported that they exhibited a significantly increased incidence of...

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Identifiers

PMID: 38572512
DOI: 10.1111/cas.16159
PMCID: PMC11145157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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