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Article

Tissue and Sex-Specific Performance of a Cancer Driver Based Biomarker in rasH2-Tg Mice.

Environmental and molecular mutagenesis - 1 Oct 2025

Harris Kelly L, Faske Jennifer B, Gong Binsheng, Parsons Barbara L

Abstract excerpt

The ability to predict rodent lifetime tumor responses from short-term exposures and a scientific basis for rodent to human extrapolation are unmet needs in cancer risk assessment. To address these needs, quantitation of cancer driver mutations (CDMs) was integrated with an error-corrected, next generation sequencing (NGS) approach. The method developed, CarcSeq, involves performing multiple, high-fidelity PCR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40799151
DOI: 10.1002/em.70027
PMCID: PMC12459003

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