Article
Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.
Carcinogenesis - 1 May 2017
Sasatani Megumi, Xi Yang, Kajimura Junko, Kawamura Toshiyuki, Piao Jinlian, Masuda Yuji, Honda Hiroaki, Kubo Kei, Mikamoto Takahiro, Watanabe Hiromitsu, Xu Yanbin, Kawai Hidehiko, Shimura Tsutomu, Noda Asao, Hamasaki Kanya, Kusunoki Yoichiro, Zaharieva Elena Karamfilova, Kamiya Kenji
Abstract excerpt
Cancer development often involves mutagenic replication of damaged DNA by the error-prone translesion synthesis (TLS) pathway. Aberrant activation of this pathway plays a role in tumorigenesis by promoting genetic mutations. Rev1 controls the function of the TLS pathway, and Rev1 expression levels are associated with DNA damage induced cytotoxicity and mutagenicity. However, it remains unclear whether deregulated...
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