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Article

Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes.

Cancer research - 14 Mar 2025

Sawant Akshada, Shi Fuqian, Cararo Lopes Eduardo, Hu Zhixian, Abdelfattah Somer, Baul Jennele, Powers Jesse R, Hinrichs Christian S, Rabinowitz Joshua D, Chan Chang S, Lattime Edmund C, Ganesan Shridar, White Eileen P

Abstract excerpt

Mutations in the exonuclease domains of the replicative nuclear DNA polymerases POLD1 and POLE are associated with increased cancer incidence, elevated tumor mutation burden (TMB), and enhanced response to immune checkpoint blockade (ICB). Although ICB is approved for treatment of several cancers, not all tumors with elevated TMB respond, highlighting the need for a better understanding of how TMB affects tumor...

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Source

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Identifiers

PMID: 39786467
DOI: 10.1158/0008-5472.CAN-24-2589
PMCID: PMC11907192

Genes

POLD1
POLE

Provenance

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