Article

REV1 inhibition enhances trinucleotide repeat mutagenesis

2025-09-16

Abstract excerpt

Trinucleotide repeat (TNR) instability has been implicated in the pathogenesis of numerous neurodegenerative disorders. Because TNR instability causes mutagenesis of the underlying gene, we refer to the repeat instability phenomenon as TNR mutagenesis in this study. While germline expansions destabilize TNR to cause disease anticipation, somatic cell TNR instability drives earlier onset of symptoms and further dis...

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Literature Corpus work: f8d5e661-3dec-5b1b-804d-c4395b676b4c
DOI: 10.1101/2025.09.11.675234

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