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Article

Involvement of Rev1 in alkylating agent-induced loss of heterozygosity in Oryzias latipes.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2020

Fujikawa Yoshihiro, Ishikawa-Fujiwara Tomoko, Kuo Tony, Shinkai Norio, Shoji Tatsuma, Kawasaki Takashi, Kamei Yasuhiro, Sakuraba Yoshiyuki, Sato Ayuko, Kinoshita Masato, Gondo Yoichi, Yuba Shunsuke, Tsujimura Tohru, Sese Jun, Todo Takeshi

Abstract excerpt

Translesion synthesis (TLS) polymerases mediate DNA damage bypass during replication. The TLS polymerase Rev1 has two important functions in the TLS pathway, including dCMP transferase activity and acting as a scaffolding protein for other TLS polymerases at the C-terminus. Because of the former activity, Rev1 bypasses apurinic/apyrimidinic sites by incorporating dCMP, whereas the latter activity mediates...

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Identifiers

PMID: 31917895
DOI: 10.1111/gtc.12746
PMCID: PMC7079036

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