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Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors

1 Mar 2024

Abstract excerpt

SMADs are the canonical intracellular effector proteins of the TGF-β (transforming growth factor-β). SMADs translocate from plasma membrane receptors to the nucleus regulated by many SMAD-interacting proteins through phosphorylation and other post-translational modifications that govern their nucleocytoplasmic shuttling and subsequent transcriptional activity. The signaling pathway of TGF-β/SMAD exhibits both...

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PMID: 38543112
DOI: 10.3390/ph17030326

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