Article
Regulation of cell proliferation by Smad proteins.
Journal of cellular physiology - 1 Apr 2002
Ten Dijke Peter, Goumans Marie-José, Itoh Fumiko, Itoh Susumu
Abstract excerpt
Transforming growth factor-beta (TGF-beta) family members which include TGF-betas, activins, and bone morphogenetic proteins (BMPs) regulate a broad spectrum of biological responses on a large variety of cell types. TGF-beta family members initiate their cellular responses by binding to distinct receptors with intrinsic serine/threonine kinase activity and activation of specific downstream intracellular effectors...
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