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Article

TGF-β Signaling in Cancer: Mechanisms of Progression and Therapeutic Targets

29 Jul 2025

Abstract excerpt

Transforming growth factor-β (TGF-β) is a key protein family member that includes activins, inhibins, and bone morphogenetic proteins (BMPs). It is essential in numerous biological processes, such as chemotaxis, apoptosis, differentiation, growth, and cell migration. TGF-β receptors initiate signaling through two primary pathways: the canonical pathway involving Smad proteins and non-canonical pathways that...

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PMID: 40806457
DOI: 10.3390/ijms26157326

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