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Smad4-mediated TGF-β signaling in tumorigenesis

1 Jan 2010

Abstract excerpt

Transforming growth factor-beta (TGF-beta) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the common mediator Smad4. The dual effects of TGF-beta signaling on tumor initiation and progression are cell-specific and yet to be determined under distinct contexts. A number of genetically manipulated mouse...

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Genetic factors in colorectal cancer
Pancreatic and Hepatic Oncology Research
TGF-β signaling in diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20087440
DOI: 10.7150/ijbs.6.1

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