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SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications

26 Aug 2023

Abstract excerpt

Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for its dual role in cancer progression as both an inhibitor of tumour cell growth and an inducer of tumour metastasis. This is mainly mediated through SMAD proteins and...

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PMID: 37685308
DOI: 10.3390/diagnostics13172769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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