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Article

Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice.

Acta pharmacologica Sinica - 1 Jul 2024

Cheng Jie, Chen Ling, Zheng Ya-Ni, Liu Juan, Zhang Lei, Zhang Xiao-Ming, Huang Liang, Yuan Qiong-Lan

Abstract excerpt

Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65-/-) mice exhibit abnormal social and mental behaviors and decreased expression of tryptophan hydroxylase 2 (TPH2) protein. However, whether a causal relationship between TPH2 reduction and anxiety disorders exists needs to...

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Source

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Identifiers

PMID: 38528118
DOI: 10.1038/s41401-024-01252-5
PMCID: PMC11192762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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