Article

TPH2 knockout male rats are aggressive, show less anxiety, and exhibit an altered oxytocin system

2022-07-10

Abstract excerpt

<h4>ABSTRACT</h4> The central serotoninergic system is critical for stress responsivity and social behavior, and its dysregulations has been centrally implicated in virtually all neuropsychiatric disorders. Genetic serotonin depletion animal models could provide a tool to elucidate the causes and mechanisms of diseases and to develop new treatment approaches. Previously mice lacking tryptophan hydroxylase 2 (Tph2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4008981c-1f8f-5ed3-bb4f-0caabff664a7
DOI: 10.1101/2022.07.08.499134

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TPH2 knockout male rats are aggressive, show less anxiety, and exhibit an altered oxytocin systemDOI 10.1101/2022.07.08.499134Read

Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin.Semantic proximity Read

Constitutive depletion of brain serotonin differentially affects rats’ social and cognitive abilitiesSemantic proximity Read

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Semantic proximity Read

Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour.Semantic proximity Read

Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin.Semantic proximity Read

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression.Semantic proximity Read

Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivitySemantic proximity Read

Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice.Semantic proximity Read

Brain serotonin determines maternal behavior and offspring survival.Semantic proximity Read

Role of TPH-2 in brain function: news from behavioral and pharmacologic studies.Semantic proximity Read