Article

Adolescent Social Isolation Facilitates Tau Spread in Raphe Nuclei, Linking Depression and Hyperalgesia in Alzheimer’s Disease

2026-01-25

Abstract excerpt

Tau pathology in brainstem serotonergic circuits drives early neuropsychiatric dysfunction in Alzheimer’s disease (AD), yet mechanisms linking the exposome, particularly social stress exposures to depression and altered pain perception, remain unclear. Here, we demonstrate that adolescent social isolation, a critical psychosocial exposome factor and major trigger of depression, facilitates tau propagation in the d...

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Literature Corpus work: c156f97d-b5b5-5307-8914-88e68e89777e
DOI: 10.64898/2026.01.23.701108

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Adolescent Social Isolation Facilitates Tau Spread in Raphe Nuclei, Linking Depression and Hyperalgesia in Alzheimer’s DiseaseDOI 10.64898/2026.01.23.701108Read

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