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Article

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2012

Berger Stefan M, Weber Tillmann, Perreau-Lenz Stephanie, Vogt Miriam A, Gartside Sarah E, Maser-Gluth Christiane, Lanfumey Laurence, Gass Peter, Spanagel Rainer, Bartsch Dusan

Abstract excerpt

The association of single-nucleotide polymorphisms (SNPs) in the human tryptophan hydroxylase 2 (TPH2) gene with anxiety traits and depression has been inconclusive. Observed inconsistencies might result from the fact that TPH2 polymorphisms have been studied in a genetically heterogeneous human population. A defined genetic background, control over environmental factors, and the ability to analyze the molecular...

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Source

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Identifiers

PMID: 22491354
DOI: 10.1038/npp.2012.46
PMCID: PMC3398728

Genes

TPH2

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A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.PMID 22491354Read ↗

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The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains.Semantic proximity Read ↗

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C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test.Semantic proximity Read ↗

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read ↗

Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin.Semantic proximity Read ↗

Role of TPH-2 in brain function: news from behavioral and pharmacologic studies.Semantic proximity Read ↗

TPH2 knockout male rats are aggressive, show less anxiety, and exhibit an altered oxytocin systemSemantic proximity Read ↗

[The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain].Semantic proximity Read ↗

No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

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