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Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion.

Neuropharmacology - 1 Jan 2012

Fernandez Sebastian P, Gaspar Patricia

Abstract excerpt

Emotional disorders such as depression, panic attacks, generalized anxiety, phobias and post-traumatic stress have been associated to decreased serotonin (5-HT) function, based on the positive effects of treatments that enhance 5-HT neurotransmission. However, it has been difficult to establish a primary role for 5-HT deficiency in these diseases, making preclinical models particularly useful. Over the last ten...

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PMID: 21945798
DOI: 10.1016/j.neuropharm.2011.08.049

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