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Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior.

Cells - 19 Nov 2021

Sidorova Maria, Kronenberg Golo, Matthes Susann, Petermann Markus, Hellweg Rainer, Tuchina Oksana, Bader Michael, Alenina Natalia, Klempin Friederike

Abstract excerpt

Serotonin (5-hydroxytryptamine, 5-HT) is a crucial signal in the neurogenic niche of the hippocampus, where it is involved in antidepressant action. Here, we utilized a new transgenic rat model (TetO-shTPH2), where brain 5-HT levels can be acutely altered based on doxycycline (Dox)-inducible shRNA-expression. On/off stimulations of 5-HT concentrations might uniquely mirror the clinical course of major depression...

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Identifiers

PMID: 34831469
DOI: 10.3390/cells10113240
PMCID: PMC8618971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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