Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2015

Weber Tillmann, Vogt Miriam A, Gartside Sarah E, Berger Stefan M, Lujan Rafael, Lau Thorsten, Herrmann Elke, Sprengel Rolf, Bartsch Dusan, Gass Peter

Abstract excerpt

Both the glutamatergic and serotonergic (5-HT) systems are implicated in the modulation of mood and anxiety. Descending cortical glutamatergic neurons regulate 5-HT neuronal activity in the midbrain raphe nuclei through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hydroxyindoleacetic Acid
Share to Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Memory

Share to Norepinephrine

Share to Receptors, Adrenergic, alpha-1

Share to Receptors, AMPA

Share to Serotonin

Share to Tryptophan Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 25547714
DOI: 10.1038/npp.2014.332
PMCID: PMC4397405

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25547714-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity.PMID 25547714Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

Serotonin 5-HT4 receptors modulate the development of glutamatergic input to the dorsal raphe nucleus.Semantic proximity Read ↗

A suite of engineered mice for interrogating psychedelic drug actionsSemantic proximity Read ↗

Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion.Semantic proximity Read ↗

Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out MiceSemantic proximity Read ↗

Characterization of serotonin neurotransmission in knockout mice: implications for major depression.Semantic proximity Read ↗

Inactivation of 5HT transport in mice: modeling altered 5HT homeostasis implicated in emotional dysfunction, affective disorders, and somatic syndromes.Semantic proximity Read ↗

New lessons from knockout mice: The role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders.Semantic proximity Read ↗

Deficits in LTP Induction by 5-HT2A Receptor Antagonist in a Mouse Model for Fragile X SyndromeSemantic proximity Read ↗

A tryptophan hydroxlyase 1 reporter that directs Cre recombinase extinguishable placental alkaline phosphatase expression in serotonergic (5-HT) neurons and peripheral tissues.Semantic proximity Read ↗

Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.Semantic proximity Read ↗

Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.