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Article

Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.

Psychoneuroendocrinology - 1 Mar 2015

Sachs Benjamin D, Rodriguiz Ramona M, Tran Ha L, Iyer Akshita, Wetsel William C, Caron Marc G

Abstract excerpt

Brain 5-HT deficiency has long been implicated in psychiatric disease, but the effects of 5-HT deficiency on stress susceptibility remain largely unknown. Early life stress (ELS) has been suggested to contribute to adult psychopathology, but efforts to study the long-term consequences of ELS have been limited by a lack of appropriate preclinical models. Here, we evaluated the effects of 5-HT deficiency on several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Serotonin, 5-HT2A

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Source

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Identifiers

PMID: 25602134
DOI: 10.1016/j.psyneuen.2014.12.019
PMCID: PMC4344834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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