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Article

Catalytic residues of microRNA Argonautes play a modest role in microRNA star strand destabilization in C. elegans.

Nucleic acids research - 22 May 2024

Kotagama Kasuen, Grimme Acadia L, Braviner Leah, Yang Bing, Sakhawala Rima M, Yu Guoyun, Benner Lars Kristian, Joshua-Tor Leemor, McJunkin Katherine

Abstract excerpt

Many microRNA (miRNA)-guided Argonaute proteins can cleave RNA ('slicing'), even though miRNA-mediated target repression is generally cleavage-independent. Here we use Caenorhabditis elegans to examine the role of catalytic residues of miRNA Argonautes in organismal development. In contrast to previous work, mutations in presumed catalytic residues did not interfere with development when introduced by CRISPR. We...

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Identifiers

PMID: 38471816
DOI: 10.1093/nar/gkae170
PMCID: PMC11109956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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