Article

Widespread destabilization of <i>C. elegans</i> microRNAs by the E3 ubiquitin ligase EBAX-1

2024-06-29

Abstract excerpt

<h4>ABSTRACT</h4> MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to form complexes that direct mRNA repression. miRNAs are also the subject of regulation. For example, some miRNAs are destabilized through a pathway in which pairing to specialized transcripts recruits the ZSWIM8 E3 ubiquitin ligase, which polyubiquitinates AGO, leading to its degradation and exposure of the miRNA to cellular nucleases....

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Literature Corpus work: d26a4f56-2622-5063-8924-d6b9d63c046d
DOI: 10.1101/2024.06.28.601170

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