Article
Defining the contribution of microRNA-specific Argonautes with slicer capability in animals.
Nucleic acids research - 22 May 2024
Pal Anisha, Vasudevan Vaishnav, Houle François, Lantin Michael, Maniates Katherine A, Huberdeau Miguel Quévillon, Abbott Allison L, Simard Martin J
Abstract excerpt
microRNAs regulate gene expression through interaction with an Argonaute protein. While some members of this protein family retain an enzymatic activity capable of cleaving RNA molecules complementary to Argonaute-bound small RNAs, the role of the slicer residues in the canonical microRNA pathway is still unclear in animals. To address this, we created Caenorhabditis elegans strains with mutated slicer residues...
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