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Article

Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal.

Proceedings of the National Academy of Sciences of the United States of America - 22 Sept 2015

Zinovyeva Anna Y, Veksler-Lublinsky Isana, Vashisht Ajay A, Wohlschlegel James A, Ambros Victor R

Abstract excerpt

MicroRNAs are regulators of gene expression whose functions are critical for normal development and physiology. We have previously characterized mutations in a Caenorhabditis elegans microRNA-specific Argonaute ALG-1 (Argonaute-like gene) that are antimorphic [alg-1(anti)]. alg-1(anti) mutants have dramatically stronger microRNA-related phenotypes than animals with a complete loss of ALG-1. ALG-1(anti) miRISC...

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Identifiers

PMID: 26351692
DOI: 10.1073/pnas.1506576112
PMCID: PMC4586838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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