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Article

Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.

Cell - 17 Nov 2006

Yigit Erbay, Batista Pedro J, Bei Yanxia, Pang Ka Ming, Chen Chun-Chieh G, Tolia Niraj H, Joshua-Tor Leemor, Mitani Shohei, Simard Martin J, Mello Craig C

Abstract excerpt

Argonaute (AGO) proteins interact with small RNAs to mediate gene silencing. C. elegans contains 27 AGO genes, raising the question of what roles these genes play in RNAi and related gene-silencing pathways. Here we describe 31 deletion alleles representing all of the previously uncharacterized AGO genes. Analysis of single- and multiple-AGO mutant strains reveals functions in several pathways, including (1)...

Topics

Amino Acid Sequence
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Embryo, Nonmammalian
Models, Genetic
Molecular Sequence Data
Mutation
Phylogeny
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Interference

RNA, Helminth

RNA, Small Interfering

Recombinant Fusion Proteins

Source

Identifiers

PMID: 17110334
DOI: 10.1016/j.cell.2006.09.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.PMID 17110334Read ↗

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