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Article

ALG-5 is a miRNA-associated Argonaute required for proper developmental timing in the Caenorhabditis elegans germline.

Nucleic acids research - 6 Sept 2017

Brown Kristen C, Svendsen Joshua M, Tucci Rachel M, Montgomery Brooke E, Montgomery Taiowa A

Abstract excerpt

Caenorhabditis elegans contains 25 Argonautes, of which, ALG-1 and ALG-2 are known to primarily interact with miRNAs. ALG-5 belongs to the AGO subfamily of Argonautes that includes ALG-1 and ALG-2, but its role in small RNA pathways is unknown. We analyzed by high-throughput sequencing the small RNAs associated with ALG-5, ALG-1 and ALG-2, as well as changes in mRNA expression in alg-5, alg-1 and alg-2 mutants....

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Share to Argonaute Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28645154
DOI: 10.1093/nar/gkx536
PMCID: PMC5587817

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