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Article

Modeling neurodevelopmental disorder-associated human AGO1 mutations in Caenorhabditis elegans Argonaute alg-1.

Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2024

Duan Ye, Li Li, Panzade Ganesh Prabhakar, Piton Amélie, Zinovyeva Anna, Ambros Victor

Abstract excerpt

MicroRNAs (miRNA) associate with Argonaute (AGO) proteins and repress gene expression by base pairing to sequences in the 3' untranslated regions of target genes. De novo coding variants in the human AGO genes AGO1 and AGO2 cause neurodevelopmental disorders (NDD) with intellectual disability, referred to as Argonaute syndromes. Most of the altered amino acids are conserved between the miRNA-associated AGO in...

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PMID: 38412125
DOI: 10.1073/pnas.2308255121
PMCID: PMC10927592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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