Article
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.
PLoS genetics - 1 Dec 2007
Miska Eric A, Alvarez-Saavedra Ezequiel, Abbott Allison L, Lau Nelson C, Hellman Andrew B, McGonagle Shannon M, Bartel David P, Ambros Victor R, Horvitz H Robert
Abstract excerpt
MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viability or...
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