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Article

Target-mediated protection of endogenous microRNAs in C. elegans.

Developmental cell - 15 Mar 2011

Chatterjee Saibal, Fasler Monika, Büssing Ingo, Grosshans Helge

Abstract excerpt

MicroRNAs (miRNAs) are tightly regulated through transcriptional and posttranscriptional mechanisms, including degradation by nucleases. Here, we report that in C. elegans, target mRNAs can protect their cognate miRNAs from degradation in vivo. We show that the let-7(n2853) mutation destabilizes the mature let-7 miRNA by impairing this protection. Moreover, presence of a cognate target or depletion of the xrn-1...

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Identifiers

PMID: 21397849
DOI: 10.1016/j.devcel.2011.02.008

Genes

XRN1
XRN2

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