Article
Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders.
Science (New York, N.Y.) - 25 Jun 2026
Liang Lifan, Zhang Siwei, Wang Zicheng, Zhang Hanwen, Li Chuxuan, Thapa Christina, Oh Emily K, Sirkin David, Sun Xiaotong, Barishman Alexandra, McCarroll Ada, Duhe Alexandra C, Qian Sheng, Zhong Xiaoyuan, Jamison Brendan, Wood Whitney, Kozlova Alena, Pang Zhiping P, Sanders Alan R, He Xin, Duan Jubao
Abstract excerpt
Most causal variants for neuropsychiatric disorders (NPD) remain unknown. A major hurdle is that disease variants may act in specific contexts, such as during neuronal activation, which is difficult to study in vivo at the population level. We profiled single-nucleus neuron-activation multiomics in human induced pluripotent stem cell-derived neurons from 100 donors, revealing the NPD-relevant transcriptomic and...
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