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Article

SOX17 enables immune evasion of early colorectal adenomas and cancers.

Nature - 1 Mar 2024

Goto Norihiro, Westcott Peter M K, Goto Saori, Imada Shinya, Taylor Martin S, Eng George, Braverman Jonathan, Deshpande Vikram, Jacks Tyler, Agudo Judith, Yilmaz Ömer H

Abstract excerpt

A hallmark of cancer is the avoidance of immune destruction. This process has been primarily investigated in locally advanced or metastatic cancer1-3; however, much less is known about how pre-malignant or early invasive tumours evade immune detection. Here, to understand this process in early colorectal cancers (CRCs), we investigated how naive colon cancer organoids that were engineered in vitro to harbour...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38418875
DOI: 10.1038/s41586-024-07135-3
PMCID: PMC11969226

Genes

SOX17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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