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Microbial Invasion and Immunosuppression Drive Adenoma Progression in Early Colorectal Cancer Development

2026-07-13

Abstract excerpt

Several inherited predispositions to colorectal cancer exist, most notably familial adenomatous polyposis (FAP), which typically involves a germline loss-of-function mutation in one APC allele. A second hit in APC or related loci leads to aberrant Wnt signalling, triggering adenoma formation with near-complete penetrance. Yet, substantial variability in disease onset and severity, even among siblings with identi...

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Literature Corpus work
690cad0d-2976-5e4e-bcc8-42713175b341
DOI
10.64898/2026.07.10.737736
Open publication

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Microbial Invasion and Immunosuppression Drive Adenoma Progression in Early Colorectal Cancer DevelopmentDOI 10.64898/2026.07.10.737736
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