Article

CD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon

2025-10-19

Abstract excerpt

<h4>Summary</h4> Epithelial cells in the colon accumulate substantial numbers of somatic mutations, some of which can be recognised as neoantigens. The ability of CD8 T cells to survey for neoantigen+ cells in the healthy colon would provide an early detection mechanism to prevent cancer, but it is unclear whether neoantigen-specific CD8 T cells can mediate this process of immunosurveillance without becoming tole...

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Literature Corpus work: f0271507-916c-51ea-8ce0-5ccb5f5c0e48
DOI: 10.1101/2025.10.19.683142

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