Article
The mutagenic source and power of our own evolution.
Advances in genetics - 1 Jan 2020
Lindley Robyn A
Abstract excerpt
This chapter addresses the molecular mechanism and source of the numerous mutagenic changes that genomes, particularly mammalian genomes, can undergo during normal development and in diseased states. The central role of pathogen and other disease-inducing innate immunity via the action of the cytosine (AID/APOBEC) and adenosine (ADAR) deaminases is reviewed in some depth. The general and universal nature of...
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