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Deaminase-Driven Reverse Transcription (DRT) Mutagenesis in Oncogenesis: Critical Analysis of Transcriptional Strand Asymmetries of Single Base Substitution (SBS) Signatures

2024-11-20

Abstract excerpt

This paper provides a critical analysis of the molecular mechanisms presently used to explain transcriptional strand asymmetries of single base substitution (SBS) signatures observed in cancer genomes curated at the Catalogue of Somatic Mutations in Cancer (COSMIC) data base (Wellcome Trust- Sanger Institute). The analysis is based on a Deaminase-driven Reverse Transcriptase (DRT) mutagenesis model of cancer oncog...

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Literature Corpus work
c46cdfab-ee75-5a36-b1ce-4281d4496006
DOI
10.20944/preprints202411.1526.v1
Open publication

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Deaminase-Driven Reverse Transcription (DRT) Mutagenesis in Oncogenesis: Critical Analysis of Transcriptional Strand Asymmetries of Single Base Substitution (SBS) SignaturesDOI 10.20944/preprints202411.1526.v1
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