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Article

Whole Genome Sequencing Analysis of Model Organisms Elucidates the Association Between Environmental Factors and Human Cancer Development.

International journal of molecular sciences - 17 Oct 2024

Hasegawa Shinya, Shoji Yutaka, Kato Mamoru, Elzawahry Asmaa, Nagai Momoko, Gi Min, Suzuki Shugo, Wanibuchi Hideki, Mimaki Sachiyo, Tsuchihara Katsuya, Totsuka Yukari

Abstract excerpt

Determining a novel etiology and mechanism of human cancer requires extraction of characteristic mutational signatures derived from chemical substances. This study explored the mutational signatures of N-nitroso bile acid conjugates using Salmonella strains. Exposing S. typhimurium TA1535 to N-nitroso-glycine/taurine bile acid conjugates induced a predominance of C:G to T:A transitions. Two mutational signatures,...

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PMID: 39456974
DOI: 10.3390/ijms252011191
PMCID: PMC11508241

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