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Article

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.

Nature communications - 31 May 2017

Isella Claudio, Brundu Francesco, Bellomo Sara E, Galimi Francesco, Zanella Eugenia, Porporato Roberta, Petti Consalvo, Fiori Alessandro, Orzan Francesca, Senetta Rebecca, Boccaccio Carla, Ficarra Elisa, Marchionni Luigi, Trusolino Livio, Medico Enzo, Bertotti Andrea

Abstract excerpt

Stromal content heavily impacts the transcriptional classification of colorectal cancer (CRC), with clinical and biological implications. Lineage-dependent stromal transcriptional components could therefore dominate over more subtle expression traits inherent to cancer cells. Since in patient-derived xenografts (PDXs) stromal cells of the human tumour are substituted by murine counterparts, here we deploy...

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PMID: 28561063
DOI: 10.1038/ncomms15107
PMCID: PMC5499209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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