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Patient-derived organoids reflect the genetic profile of endometrial tumors and predict patient prognosis

30 Jul 2021

Abstract excerpt

Background: A major hurdle in translational endometrial cancer (EC) research is the lack of robust preclinical models that capture both inter- and intra-tumor heterogeneity. This has hampered the development of new treatment strategies for people with EC. Methods: EC organoids were derived from resected patient tumor tissue and expanded in a chemically defined medium. Established EC organoids were orthotopically...

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PMID: 35602206
DOI: 10.1038/s43856-021-00019-x

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