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Article

Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs.

In vitro cellular & developmental biology. Animal - 1 Aug 2024

Nguyen Thanh-Van, Takebayashi Koki, Do Lanh Thi Kim, Namula Zhao, Wittayarat Manita, Nagahara Megumi, Hirata Maki, Otoi Takeshige, Tanihara Fuminori

Abstract excerpt

The generation of genetically engineered pig models that develop pancreas-specific tumors has the potential to advance studies and our understanding of pancreatic cancer in humans. TP53 mutation causes organ-nonspecific cancers, and PDX1-knockout results in the loss of pancreas development. The aim of the present study was to generate a PDX1-knockout pig chimera carrying pancreas complemented by TP53 mutant cells...

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Identifiers

PMID: 38379097
DOI: 10.1007/s11626-024-00870-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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