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Xenogeneic transplantation and tolerance in the era of CRISPR-Cas9

22 Nov 2018

Abstract excerpt

PURPOSE OF REVIEW: The use of genetically modified donor pigs has been integral to recent major advances in xenograft survival in preclinical nonhuman primate models. CRISPR-Cas9 gene editing technology has dramatically accelerated the development of multimodified pigs. This review examines the current and projected impact of CRISPR-Cas9-mediated donor modification on preventing rejection and potentially...

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PMID: 30480643
DOI: 10.1097/mot.0000000000000589

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