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Article

Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer.

Journal of translational medicine - 3 Nov 2017

Shen Youfeng, Xu Kaixiang, Yuan Zaimei, Guo Jianxiong, Zhao Heng, Zhang Xuezeng, Zhao Lu, Qing Yubo, Li Honghui, Pan Weirong, Jia Baoyu, Zhao Hong-Ye, Wei Hong-Jiang

Abstract excerpt

BACKGROUND: Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from oncogenic transformation and is mutated in a large number of human cancers. P53 mutations occur in almost every type of tumor and in over 50% of all tumors. In a recent publication, pigs with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29100547
DOI: 10.1186/s12967-017-1327-0
PMCID: PMC5670695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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