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Article

Generation of viable PDX1 gene-edited founder pigs as providers of nonmosaics.

Molecular reproduction and development - 1 Apr 2020

Tanihara Fuminori, Hirata Maki, Thi Nguyen Nhien, Anh Le Quynh, Hirano Takayuki, Otoi Takeshige

Abstract excerpt

Pancreatic duodenal homeobox 1 (PDX1) is a crucial gene for pancreas development during the fetal period. PDX1-modified pigs have the potential to be used as a model of diabetes mellitus. However, the severe health problems caused by the PDX1 mutation limit phenotypic studies of PDX1-modified pigs as diabetes models. In this study, we generated PDX1-modified pigs by the CRISPR/Cas9 system introduced into zygotes...

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PMID: 32166879
DOI: 10.1002/mrd.23335

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