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CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs

30 Aug 2017

Abstract excerpt

Genome editing using programmable nucleases has revolutionized biomedical research. CRISPR-Cas9 mediated zygote genome editing enables high efficient production of knockout animals suitable for studying development and relevant human diseases. Here we report efficient disabling pancreatogenesis in pig embryos via zygotic co-delivery of Cas9 mRNA and dual sgRNAs targeting the PDX1 gene, which when combined with...

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PMID: 28874671
DOI: 10.1038/s41598-017-08596-5

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