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Production of Four‐Gene (GTKO/hCD55/hTBM/hCD39)‐Edited Donor Pigs and Kidney Xenotransplantation

1 Jul 2024

Abstract excerpt

BACKGROUND: The number of multigene-modified donor pigs for xenotransplantation is increasing with the advent of gene-editing technologies. However, it remains unclear which gene combination is suitable for specific organ transplantation. METHODS: In this study, we utilized CRISPR/Cas9 gene editing technology, piggyBac transposon system, and somatic cell cloning to construct GTKO/hCD55/hTBM/hCD39 four-gene-edited...

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PMID: 39185796
DOI: 10.1111/xen.12881

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