Article

Production of four-gene (GTKO/hCD55/hTBM/hCD39)-edited donor pigs and kidney xenotransplantation

2024-05-21

Abstract excerpt

<h4>Background</h4> The number of multigene-modified donor pigs for xenotransplantation is increasing with the advent of gene editing technologies. However, which gene combination is suitable for which organ transplantation remains unclear. <h4>Methods</h4> In this study, we utilized CRISPR/Cas9 gene editing technology, PiggyBac transposon system and somatic cell cloning to construct GTKO/hCD55/hTBM/hCD39 four-g...

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Literature Corpus work: 940e266c-4d31-5f07-91ed-e5847c781d1b
DOI: 10.1101/2024.05.19.594896

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