Article

Production and functional verification of 8-gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)-edited donor pigs for xenotransplantation

2024-05-20

Abstract excerpt

Gene-edited pig-to-human xenotransplantation continues to make breakthroughs and is expected to enter clinic to solve the global shortage of donor organs. However, which gene combination is suitable for which organ transplantation remains unclear. In this study, we utilized CRISPR/Cas9 gene editing technology, PiggyBac transposon system and somatic cell cloning to construct GTKO/CMAHKO/β4GalNT2KO/hCD46/hCD55/hCD59...

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Literature Corpus work: d3b52bb7-2121-5967-aa86-1a2dbb9f349c
DOI: 10.1101/2024.05.19.594889

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Production and functional verification of 8-gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)-edited donor pigs for xenotransplantationDOI 10.1101/2024.05.19.594889Read

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