Article

Site-specific N6-methyladenosine fine tunes CTCF/cohesin-defined enhancer-promoter interactions and oncogenic transcription program

2026-08-14

Abstract excerpt

<title>Abstract</title> N6-methyladenosine (m6A) of RNAs plays an important role in RNA stability and gene expression. However, it remains unknown how site-specific m6A on individual RNA is decoded to regulate chromatin architecture and transcriptional reprogramming. Here, we show that m6A modification of HOTTIP lncRNA is highly enriched in acute myeloid leukemia (AML) patients carrying MLL-rearrangement (MLLr...

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Literature Corpus work: 44563740-5baf-598e-80b1-0fe3822ce2ba
DOI: 10.21203/rs.3.rs-10010180/v1

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