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Article

ADAR1 Prevents R-loop Accumulation-Driven ATR Pathway Activation in Ovarian Cancer

2020-11-12

Abstract excerpt

<h4>Background: </h4> Adenosine (A)-to-inosine (I) RNA editing is the most prevalent RNA editing mechanism, in which adenosine deaminases acting on RNA 1 (ADAR1) is a major adenosine deaminase. Increasing evidence suggests that editing dysregulation of ADAR1 plays an important role in human tumorigenesis, while the underlying mechanism remains elusive. MethodsThe clinical relevance of ADAR1 was analyzed by real-ti...

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Literature Corpus work
9e437f1b-9d36-5d3f-9dc7-74ec7db02297
DOI
10.21203/rs.3.rs-103651/v1
Open publication

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ADAR1 Prevents R-loop Accumulation-Driven ATR Pathway Activation in Ovarian CancerDOI 10.21203/rs.3.rs-103651/v1
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