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Article

ARID1A and Its Impact Across the Hallmarks of Cancer

13 May 2025

Abstract excerpt

ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, has emerged as a pivotal tumor suppressor altered in a broad range of human malignancies. Its frequent inactivation across diverse cancer types has revealed pleiotropic roles that intersect multiple Hallmarks of Cancer. In this review, we integrate current knowledge on how ARID1A loss influences cellular processes including proliferative signaling,...

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Cancer Mechanisms and Therapy
Chromatin Remodeling and Cancer
Peptidase Inhibition and Analysis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40429787
DOI: 10.3390/ijms26104644

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