Article

ARID1A regulates R-loop associated DNA replication stress

2020-11-16

Abstract excerpt

<h4>ABSTRACT</h4> ARID1A is lost in up to 7% of all cancers, and this frequency increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in about 50% of cases. While the impact of ARID1A loss on the function of the BAF chromatin remodeller complexes is likely to drive oncogenic gene expression programs in specific contexts, ARID1A also binds genome stability regulators...

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Literature Corpus work: f48f0016-70ff-5db8-a722-2f604ff32cad
DOI: 10.1101/2020.11.16.384446

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