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Article

ARID1A regulates R-loop associated DNA replication stress

7 Apr 2021

Abstract excerpt

ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in about 50% of cases. While the impact of ARID1A loss on the function of the BAF chromatin remodeling complexes is likely to drive oncogenic gene expression programs...

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PMID: 33826602
DOI: 10.1371/journal.pgen.1009238

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